The Trump administration is warning Harvard University that it could take over its patents, worth hundreds of millions of dollars, if a review finds the university hasn’t complied with federal law, an escalation of the continuing negotiations between the White House and America’s oldest university.

The Commerce Department is launching an immediate review of the intellectual property Harvard has derived from federally funded research grants.

In a letter sent to Harvard President Alan M. Garber on Friday, Commerce Secretary Howard Lutnick alleges the university failed to follow several regulations outlined in federal law.