However, Iran has already made clear that its right to enrich uranium is not negotiable. When asked about Rubio's comments, a senior Iranian official, close to Iran's negotiating team, again said on Wednesday "zero enrichment is unacceptable."

Secretary of State Marco Rubio said in an interview released Wednesday that Iran must give up all nuclear enrichment if it wants to make a deal during talks with the Trump

Negotiations between Iran and the U.S. over Tehran’s rapidly advancing nuclear program will proceed Wednesday.

The United States and Iran are due to hold their second round of nuclear talks on Saturday, as what both sides are looking for in a deal begins to take shape.

The US president insisted that he and his Israeli counterpart are on the 'same side of every issue,' as Israel vows to act against Iran's nuclear ambitions despite renewed diplomatic efforts.