The AMP-activated protein kinase (AMPK) system was discovered in mammalian cell extracts as activities that phosphorylated and inactivated key enzymes of lipid biosynthesis, that is, acetyl-CoA ...

Adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays an important role in cellular energy homeostasis, helping in growth regulation and metabolic reprogramming in eukaryotes. The AMPK ...

Researchers at the Salk Institute report they might have solved the long-standing mystery around how the protein complex AMPK can both hinder and help cancer. The lab of Reuben Shaw, Ph.D., director ...

This graphic illustration of a study in Cell Reports shows how a molecular energy regulator in cells, AMPK, is required for astrocytic glycoses, lactate production and lactate shuttle to bio-energize ...

Grahame Hardie received funding from Cancer Research UK for this research. The basic unit of all living things is the cell – and the human body contains tens of trillions of them. Cancer can be ...

Physical activity benefits diabetics and others with insulin resistance. One of the reasons is that a single bout of physical activity increases the effectiveness of insulin. Thus, physical activity ...

Long thought to suppress cancer by slowing cellular metabolism, the protein complex AMPK also seemed to help some tumors grow, confounding researchers. Now, Salk Institute researchers have solved the ...

Most breast cancers utilize the female hormone estrogen to grow, so drug-induced estrogen deprivation is used as a treatment in many patients. However, cancer will recur in one-third of these patients ...