Conventional studies on stem cell fates are primarily focused on transcription factors, with the limited consideration for 3D genome architecture. The cohesin complex dynamically restructures ...

A new study published in Nature Biotechnology shows that stem cell differentiation is linked to cellular structures called P-bodies, providing a potential means of controlling cell identity.

Caenorhabditis elegans has long been established as a model organism for investigating the molecular determinants of organogenesis and cell fate specification. Vulval development exemplifies a highly ...

In single-cell research, understanding how stochasticity in gene transcription influences phenotypic heterogeneity within isogenic cell populations represents a fundamental question. Fluctuations in ...

Researchers from Kyushu University have developed an innovative computational method, called ddHodge, that can reconstruct the complex dynamics of how cells decide their fate. As reported in Nature ...

A cell can act in astonishingly complex ways. It must decide for itself whether to grow and multiply, rest, specialise, age or die. This applies just as much to mammalian cells as it does to seemingly ...

Shedding light on what determines how cells become what they are meant to be—nerves, bone, muscles, etc.—can also help researchers understand how diseases develop when these biological programs break ...