A peptide bridge is designed to construct a fusion enzyme with electrostatic cofactor channeling, reducing NADPH input by two orders of magnitude or decreasing reaction time threefold with the same ...

Scientists describe a novel protein that spurs the post-translational modifications of the amino acid tryptophan to create an enzyme cofactor. This work may lead to the creation of new biological ...

Chemical structure for thiamine pyrophosphate and protein structure of transketolase. Thiamine pyrophosphate cofactor in yellow and xylulose 5-phosphate substrate in black. Credit: Thomas ...

A new artificial intelligence-powered tool can help researchers determine how well an enzyme fits with a desired target, helping them find the best enzyme and substrate combination for applications ...

The research, published in The FEBS Journal, improves understanding of classical homocystinuria, a hereditary metabolic disorder, and proposes new potential therapeutic approaches. This genetically ...

Enzymology is the study of enzymes and enzyme-catalyzed reactions. Enzymes are biological catalysts that accelerate the rate of biological reactions. They can also perform multiple reactions ...

In practical applications, nothing determines the success of a biocatalysis project more than the precise match between the enzyme and the substrate. Many industrial projects encounter issues such as ...

Hot vents in the deep sea are home to microbes that feed on ethane. Now researchers have succeeded in finding an important component in the microbial conversion of the gas. They were able to decode ...