Nature

Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site

The structure of a folded core of IL-16 is similar to that of intracellular protein modules called PDZ domains. IL-16 is thus the first extracellular protein found to have a PDZ-like fold. However, it ...
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Elevated Levels of Interleukin 17A and Kynurenine in Candidemic Patients, Compared With Levels in Noncandidemic Patients in the Intensive Care Unit and Those in Healthy Controls

Background. The interplay between Candida species and pattern recognition receptors, interleukins, kynurenine, and T cells has been studied in murine and ex vivo human studies, but data are lacking ...
JSTOR Daily

Tumor Necrosis Factor-α, Interleukin-6, and Interleukin-8 Secretion and the Acute-Phase Response in Patients with Bacterial and Tuberculous Osteomyelitis

Osteomyelitis, or bone infection, is a major worldwide cause of morbidity. Treatment is frequently unsatisfactory, yet little is known about pathogenesis of infection. Plasma tumor necrosis factor ...
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Randomized placebo-controlled clinical trial of high-dose interleukin-2 in combination with a soluble p75 tumor necrosis factor receptor immunoglobulin G chimera in patients ...

Critical analysis of the current American Joint Committee on Cancer staging system for cutaneous melanoma and proposal of a new staging system. A randomized, double-blind, placebo-controlled trial was ...