The Guardians reached the quarter mark of the 2025 season on Sunday, in a 3-0 loss to the Phillies at Progressive Field in the rubber match of a three-game series.

Preview the May 10 matchup between the Philadelphia Phillies and Cleveland Guardians with odds over/under, game spread, betting lines and more.

SportsLine's proven model has simulated the Philadelphia Phillies vs. Cleveland Guardians 10,000 times and released its MLB best bets

The Philadelphia Phillies take on the Cleveland Guardians in the third and decisive game of their interleague series on Sunday Night Baseball.

The MLB rolls out an excellent 15-game slate to close out the weekend. I’ve sifted through the pitching matchups and narrowed in on a trio of No Runs First Inning (NRFI) bets from today’s loaded schedule.

Our MLB prop picks don't see Zack Wheeler having the easiest of times on the mound tonight due to multiple circumstances out of his control. That should work to Jose Ramirez's advantage on Sunday Night Baseball.

The Phillies come to town following a three-game sweep of the Rays in Tampa Bay. Last night Philly won 7-6 in ten innings. Bryson Stott went 2-4 and drove in three runs in the win. Cleveland was off yesterday following a series in Washington. Wednesday, Cleveland outslugged the Nats 8-6. Gabriel Arias went 4-5 in the win.

Which brings us to our question of the day: which is your favorite interleague matchup to watch when the Phillies are involved? Maybe you enjoy the AL East teams that are considered the Phillies’ “rivals”. Maybe you like the novelty of seeing teams from the AL West. There has to be one matchup that always catches your fancy.

Preview the May 11 matchup between the Philadelphia Phillies and Cleveland Guardians with recent trends, how to watch, livestream info, and more.