The carving up of the amyloid precursor protein (APP) by the successive action of β- and γ-secretases liberates Aβ, but also yields a small intracellular fragment, the APP intracellular domain (AICD).

DEAR DR. ROACH: I’m an 88-year-old female who has been diagnosed with ventricular fibrillation. My cardiac electrophysiology doctor, who implanted a conventional pacemaker four years ago, has noticed ...

The current issue of Neuron contains a scientific debate that bears watching. It is about one of the great mysteries of amyloid-β precursor protein (APP), that is, its physiological role. Scientists ...

Dear Dr. Roach: I’m an 88-year-old female who has been diagnosed with ventricular fibrillation. My cardiac electrophysiology doctor, who implanted a conventional pacemaker four years ago, has noticed ...