For decades, the biology of the intestinal stem cells was considered analogous to that of well-studied hematopoietic stem ...

The necrosome is the key macromolecular signaling platform initiating necroptosis, i.e., a RIPK1/RIPK3-dependent program of cell death with an important role in the control of inflammation in ...

Genome‐, transcriptome‐ and proteome‐wide measurements provide insights into how biological systems are regulated. However, fundamental aspects relating to which human proteins exist, where they are ...

During PINK1- and Parkin-mediated mitophagy, autophagy adaptors are recruited to damaged mitochondria to promote their selective degradation. Autophagy adaptors such as optineurin (OPTN) and NDP52 ...

The protein expression profile of ACE2, suggested as host receptor for SARS‐CoV‐2, is assessed in various human organs. Notably, limited ACE2 expression is observed in the respiratory system both on ...

The recent scandal surrounding Facebook and Cambridge Analytica 5 shows that these aspects of security and privacy are often not taken into account. Cambridge Analytica, a British consulting firm, was ...

Gpx4 and TRF are PPARα target genes involved in ferroptosis regulation. Loss of PPARα aggravates iron overload‐induced ferroptosis in vivo, while activation of PPARα is sufficient to largely alleviate ...

Only about 5 years after the first preclinical proof of concept for gene therapy of otoferlin-related auditory synaptopathy (Al-Moyed et al, 2018; Akil et al, 2019), preliminary reports from several ...

1 Institute of Pediatrics, Children's Hospital of Fudan University, Shanghai, China 2 The Shanghai Key Laboratory of Medical Epigenetics, The International Co‐laboratory of Medical Epigenetics and ...

Review Process Files De-emphasis of confidential comments Referee cross-commenting Co-review The EMBO Press journals use a fair and transparent process to rapidly publish important science.

The inner membrane of the mitochondrion folds inwards, forming the cristae. This folding allows a greater amount of membrane to be packed into the mitochondrion. The data in this study demonstrate ...

Centriole duplication relies on precisely timed engagement and disengagement of mother and daughter centrioles. This study reveals the multimodal, cell cycle-dependent mechanisms coordinating ...