At the end of the new Lilo & Stitch, the titular young girl Lilo (Maia Kealoha) does not remain with her older sister Nani as her parental guardian. Instead, Nani chooses to let the state decide Lilo's fate, and goes off to college.

For the most part, the new version sticks pretty closely to the 2002 animated film. The story centers on two sisters, Lilo and Nani, who are navigating life after the death of their parents. Nani, a teenager just about to head to college, struggles to hold down a job and watch out for her sister, who is a bit chaotic.