BMJ

FRI0016 R835, A NOVEL IRAK1/4 DUAL INHIBITOR IN CLINICAL DEVELOPMENT, BLOCKS TOLL-LIKE RECEPTOR 4 (TLR4) SIGNALING IN HUMAN AND MOUSE

Background: Toll-Like Receptors (TLR) and Interleukin-1 Receptors (IL-1R) play a critical role in the innate immune response as microbial sensors, providing a bridge between the innate and adaptive ...
BMJ

Modification and validation of the Birmingham Vasculitis Activity Score (version 3)

Background: Comprehensive multisystem clinical assessment using the Birmingham Vasculitis Activity score (BVAS) is widely used in therapeutic studies of systemic vasculitis. Extensive use suggested a ...
BMJ

Anti-CD20 monoclonal antibody (rituximab) as an adjunct in the treatment of giant cell arteritis

1 Department of Rheumatology, University College London Hospitals, Arthur Stanley House, 40-50 Tottenham Street, London W1T 4NJ, UK 2 Institute of Nuclear Medicine, University College London Hospitals ...
BMJ

Diagnosis of gout in patients with asymptomatic hyperuricaemia: a pilot ultrasound study

1 Division of Rheumatology, La Paz University Hospital, Madrid, Spain 2 Division of Internal Medicine, La Paz University Hospital, Madrid, Spain 3 Division of Clinical Biochemistry, La Paz University ...
BMJ

Comparison of the accuracy of steroid placement with clinical outcome in patients with shoulder symptoms

a St Vincent’s Hospital, Dublin, Ireland: Department of Rheumatology , b Department of Radiology Dr O FitzGerald, Department of Rheumatology, St Vincent’s Hospital, Elm Park, Dublin 4, Republic of ...
BMJ

Primary Sjögren's syndrome and malignancy risk: a systematic review and meta-analysis

Department of Laboratory Diagnostics, Changzheng Hospital, Second Military Medical University, Shanghai, China Correspondence to Dr Yang Zaixing and Professor Renqian Zhong, Department of Laboratory ...
BMJ

Treatment of autoinflammatory diseases: results from the Eurofever Registry and a literature review

23 Istituto Giannina Gaslini, Pediatria II, Reumatologia and Universià degli Studi di Genova, Genova, Italy 24 Istituto Giannina Gaslini, Pediatria II, Reumatologia, Genova, Italy Correspondence to ...
BMJ

Takayasu arteritis is characterised by disturbances of B cell homeostasis and responds to B cell depletion therapy with rituximab

3 Department of Pediatric Rheumatology, Charité-Universitätsmedizin Berlin, Berlin, Germany 4 Department of Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany 5 Department of Nuclear ...
BMJ

Serious infection across biologic-treated patients with rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis

Correspondence to Dr Andrew I Rutherford, Academic Rheumatology, NIHR Biomedical Research Centre at Guy’s and St Thomas' NHS Foundation Trust and King’s College, Weston Education Centre, King’s ...
BMJ

Raised erythrocyte sedimentation rate signals heart failure in patients with rheumatoid arthritis

Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA Correspondence to: Dr Sherine E Gabriel Department of Health Sciences Research, Mayo Clinic, 200 1st St SW, Rochester, MN ...
BMJ

EULAR recommendations for the treatment of systemic sclerosis: 2023 update

Objectives To update the 2017 European Alliance of Associations for Rheumatology (EULAR) recommendations for treatment of systemic sclerosis (SSc), incorporating new evidence and therapies. Methods An ...
BMJ

Ivarmacitinib, a selective Janus kinase 1 inhibitor, in patients with moderate-to-severe active rheumatoid arthritis and inadequate response to conventional synthetic DMARDs ...

Objective To assess the efficacy/safety of ivarmacitinib, a selective Janus kinase (JAK) 1 inhibitor, in patients with moderate-to-severe active rheumatoid arthritis (RA) who had an inadequate ...