The sequence pattern matters: Interruptions or “hitches” and loss of these within the C-A-G repeat and C-C-G repeat stretches play a major role as to when symptoms start with loss of interruptions ...

9 min read | January 2026 HD research recap: SKY-0515 shows promising safety data, community advocacy helps secure critical ...

Huntington’s disease (HD) is a fatal brain disorder caused by a defect in the huntingtin (HTT) gene, which produces an extra-long protein. This defect causes the HTT protein to form harmful clumps, or ...

Skyhawk Therapeutics has announced results from a Phase 1 clinical study of its experimental huntingtin-lowering drug, SKY-0515. As with all Phase 1 studies, the main goal was to understand safety and ...

Ray completed his Bachelor’s degree at the University of Toronto, Victoria College, and continued on to his graduate studies in the Department of Medical Genetics and Microbiology at the C.H. Best ...

Sleep problems are nearly universal in Huntington’s disease (HD) with up to 90% of people with HD reporting sleep-related issues. But new research from a Spanish team suggests these nighttime ...

If you’ve tried to follow Huntington’s disease (HD) clinical trials recently, you’ll know the feeling: so many trials, so many acronyms, and so many announcements. It’s a fantastic problem to have!

The Huntington’s disease (HD) community has shown its collective power over the past two months, rallying together to advocate for the continued advancement of AMT-130, uniQure’s investigational gene ...

A recent article in the scientific journal, Nature describes “A natural experiment on the effect of herpes zoster (shingles) vaccination on dementia”. This study makes similar conclusions to other ...