Objective probability estimates the odds of an event occurring through data analysis. It uses concrete measures instead of guesses to provide a reliable forecast.

Background Pharmacotherapy combinations have been shown to improve survival and reduce hospitalisations in adults with chronic heart failure with reduced ejection fraction (HFrEF); however, their cost ...

In this video interview, Marc Buyse, ScD, founder and CEO of IDDI, examines the most common threats to trial data reliability, including opaque methodologies, synthetic controls, and the limits of ...

In the 20th-century statistics wars, Bayesians were underdogs. Now their methods may help speed treatments to market.

As rare disease trials face persistent feasibility challenges, Bayesian designs are gaining momentum by enabling more flexible, data-driven approaches that integrate prior knowledge, reduce sample ...

Objectives High-dose rifamycin (HDR) regimens have demonstrated significant potential in tuberculosis (TB) treatment. This study aims to evaluate the efficacy and safety profile of different HDR ...

This study proposes an important new approach to analyzing cell-count data, which are often undersampled and cannot be accurately assessed using traditional statistical methods. The case studies ...

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. In this paper, we introduce a methodology to improve upon the ...

This important study presents a meta-analysis confirming a statistically significant association between slow oscillation-spindle coupling and memory formation, although the reported effects are ...

In the predawn hours of August 19, 2024, bolts of lightning began to fork through the purple-black clouds above the Mediterranean. From the rail of a 184-foot vessel, a 22-year-old named Matthew ...

Objectives The use of cerebral embolic protection (CEP) during transcatheter aortic valve implantation (TAVI) has been studied in several randomised trials. We aimed to perform a systematic review and ...