Network control theory can describe the photochemical isomerization of glucose to allose. This transformation, in which the hydroxy group on a single carbon flips from one stereochemical configuration ...

Polytheonamides are extensively modified peptides produced by bacteria in the microbiomes of marine sponges. These pore-forming peptides are toxic to cells, which makes them intriguing as possible ...

D-allulose, also known by the name D-psicose or just allulose, is a rare keto-sugar epimer of D-fructose in the third carbon (C 3), and naturally occurs in small quantity in fruits such as grapes and ...

Thalidomide, one of the most infamous drugs of all, caused severe birth defects in the children of pregnant women who took the drug for nausea in the 1950s. Its story has been repeated over and over – ...

Chemists report a concise synthesis of pleurotin by way of the Diels-Alder reaction and a radical epimerization. Their late-stage intermediate intersects a milestone 1988 synthesis, reducing the total ...

Nonribosomal peptide synthetases (NRPSs) are large, multidomain biosynthetic enzymes involved in the assembly-line–like synthesis of numerous peptide natural products. Among these are clinically ...

Azlactones are versatile heterocycles employed in a diversity of transformations; the main drawback of these cycles consists in the epimerization of the α-carbonyl stereocenter during its preparation.

USP's Therapeutic Peptides Expert Panel discusses manufacturing processes and impurity control for synthetic peptide APIs. The United States Pharmacopeia (USP) Therapeutic Peptides Expert Panel was ...

Tyrocidine, a macrocyclic decapeptide from Bacillus brevis, is nonribosomally assembled by a set of multimodular peptide synthetases, which condense two D-amino acids and eight L-amino acids to ...

Nonribosomal peptide synthetases are versatile engines of bioactive natural product biosynthesis that function according to the multiple carrier thiotemplate mechanism. C-terminal thioesterase (TE) ...