The Chicago Cubs (39-24) and Detroit Tigers (42-23) play the second game of their 3-game series Saturday. First pitch from Comerica Park is set for 1:10 p.m. ET (MLB Network). Let's analyze BetMGM Sportsbook's MLB odds around the Cubs vs. Tigers odds and make our expert MLB picks and predictions for the best bets.

Baseball's two best teams will meet this weekend not in Los Angeles or New York or Philadelphia. The AL-best Detroit Tigers will host the NL-best Chicago Cubs for a three-game interleague series at Comerica Park.

The Chicago Cubs came into Motown as the highest-scoring team in baseball, putting up 5.74 runs per game, one of only four teams touching the five-run plateau. However, they were limited to a run on nine hits while leaving six runners on base and going a rough 1-for-8 with runners in scoring position on Friday.