In ALS, the loss of certain proteins turns off a gene called UNC13A that needs to stay active for nerve cell communication, a ...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that causes progressive muscle weakness. A research ...

Researchers are one step closer to finding a common target for treating ALS - a fatal neurodegenerative disease that causes ...

ALS-associated RNA-binding proteins promote UNC13A transcription through REST downregulation - (https://www.embopress.org/doi ...

UNC13A is an essential regulator of neurotransmitter release at synapses and is one of a number of pre-mRNAs that becomes mis-spliced due to loss of nuclear TDP-43 in disease.

The researchers now view restoring normal UNC13A production as a possible new strategy for therapies against ALS and FTD. It’s worth noting that several scientists from Maze Therapeutics, a ...

Under the terms of the agreement, QurAlis granted Lilly an exclusive, worldwide license to develop and commercialize QRL-204 and other UNC13A-targeting compounds in exchange for an upfront payment ...

One of them, UNC13A, immediately caught Gitler’s eye. That’s because the protein, which regulates how neurons send chemical signals to one another, had been linked to ALS in previous genetic ...

UNC13A is a regulator of neurotransmitter release at synapses and is one of several pre-mRNAs that becomes mis-spliced due to loss of nuclear TDP-43 in disease.

UNC13A enables neurons (nerve cells) to communicate with each other via neurotransmitter release, and data from animal models suggests its loss from neurons can be fatal.