Janus kinase inhibitor - Wikipedia
JAK enzymes are part of the JAK/STAT pathway. This signaling pathway transmits chemical signals from the outside of cells, specifically lymphocytes, and into the cell nucleus.
JAK Inhibitors: Uses, Types, Side Effects, and More
Aug 23, 2025 · In this article, learn about the dosage, uses, and ongoing research underway for JAK inhibitors available in the United States, as well as common side effects, contraindications, and …
What are JAK inhibitors and how do they work? - Drugs.com
Jul 15, 2025 · Janus kinase (JAK) inhibitors are a group of medicines that help block immune system signals in the body that can lead to swelling (inflammation) and pain in conditions like rheumatoid …
JAK inhibitors: an evidence-based choice of the most appropriate ...
Recently, Janus kinase inhibitors (JAKi) have been developed to block the effect of proinflammatory cytokines in IMIDs.
List of the 9 Leading JAK Inhibitor Drugs - GoodRx
Aug 13, 2024 · JAK inhibitors like Xeljanz, Rinvoq, and Opzelura can treat inflammatory conditions and even alopecia. View this list of JAK inhibitors to learn about their various uses.
Definition of JAK inhibitor - NCI Dictionary of Cancer Terms
Some JAK inhibitors are used to treat cancer. They are a type of targeted therapy. Also called Janus kinase inhibitor.
Overview of the Janus kinase inhibitors for rheumatologic ... - UpToDate
Oct 22, 2025 · The Janus kinases (JAKs) are protein tyrosine kinases (TYKs) that bind to transmembrane type 1 and type 2 cytokine receptors and mediate cellular responses to numerous …
JAK inhibitors (JAKi): Mechanisms of action and perspectives in ...
Feb 1, 2025 · Understanding the cell signaling pathway, and more specifically the JAK STAT pathway, is a breakthrough in the era of biotherapies. JAKi are increasingly designed to target a single JAK …
The Safety and Efficacy of JAK Inhibitors: Have We Found the Right ...
May 15, 2025 · Among drug therapies, Janus kinase (JAK) inhibitors are an important class of drugs that have shown significant efficacy in the treatment of autoimmune and inflammatory diseases. …
10 JAK Inhibitor Side Effects to Know About - GoodRx
Apr 8, 2024 · Janus kinase (JAK) inhibitors are medications that affect the immune system. They treat health conditions such as rheumatoid arthritis, ulcerative colitis, and COVID-19.