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jove.com
Video: Preparation of Carboxylic Acids: Hydrolysis of Nitriles
4.8K Views. Nitriles (R–CN) can be converted into carboxylic acids (R–COOH) upon treatment with aqueous acids, i.e., upon hydrolysis of nitriles. Under base-catalyzed conditions, carboxylate anions (R–COO−) are formed.
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SOLVED:Acid-catalyzed hydrolysis of a nitrile to give a carboxylic acid occurs by initial protonation of the nitrogen atom, followed by nucleophilic addition of water. Review the mechanism of base-catalyzed nitrile hydrolysis in Section 20-7 and then predict the products for each reaction below and write all of the steps involved in the acid-catalyzed reaction, using curved arrows to represent electron flow in each step.
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