Remember this? May be time to screen. A Cologuard test is intended to screen adults 45 and older at average risk for colorectal cancer. Do not use if you have had adenomas, have inflammatory bowel disease and certain hereditary syndromes, or a personal or family history of colorectal cancer. Cologuard is not a replacement for colonoscopy in high risk patients. Cologuard performance in adults ages 45-49 is estimated based on a large clinical study of patients 50 and older. False positive and fals